Endocrine Abstracts

Wolfram syndrome is a rare, autosomal recessive entity characterized by several progressive neurodegenerative manifestations.Observation: We report the case of a 27-year-old patient from a Consanguineous marriage, followed for hypogonadism with delayed puberty and insulin-requiring diabetes since the age of 13 with negative autoantibodies. His diabetes is complicated after 5 years of a mainly vegetative neuropathy with neurogenic bladder complicated by b...

Introduction: Several studies have incriminated hypomagnesemia in the pathophysiology of diabetes, as the prevalence of this deficit in type 2 diabetics is high, and as it is correlated with glycemic control and chronic diabetic complications.Aims: Studying the prevalence of hypomagnesemia in type 2 diabetics and assessing its impact on quality of life, glycemic control and chronic diabetic complications. Patients and methods: We conducted a descriptive ...

Introduction: Growth hormone deficiency (GHD) is a rare cause of growth retardation whose diagnosis remains relatively late. Its etiologies are multiple, and its treatment could improve the stature prognosis of the children. The objective of this study was to describe the clinical, biological, radiological, and therapeutic characteristics of GHD, and its outcomes after treatment.Methods: A cross-sectional study was conducted in the Endocrinology departme...

Introduction : Few studies have considered the natural history of pituitary anatomy in Sheehan syndrome (SS), as seen on magnetic resonance imaging (MRI) or CT scan. An imaging study of the sella turcica was carried out in patients with SS. The aim was to look for correlations between radiological findings and the degree of endocrine insufficiency on the one hand, and diagnosis delay on the other.Methods: This is a retrospective study carried out between...

Introduction: Sheehan’s syndrome (SS) results from severe post-partum hemorrhage leading to necrosis of the pituitary gland. Here we describe the clinical characteristics of patients with Sheehan syndrome.Methods: We conducted a 44-year cohort study (1977 to 2021) of patients with SS followed at the endocrinology department of Farhat Hached Hospital in Sousse, Tunisia. Medical history, physical examination findings and laboratory investigations were...

Introduction: Hamartomas are benign tumors that occur in many different parts of the body. Brain locations of hamartoma are rare but still reported in few cases such as the tuber cinereum (TC) location. Children with hypothalamic hamartomas develop precocious puberty generally associated with gelastic seizures. However, TC hamartomas do not necessarily induce clinical symptoms. Amenorrhea has never been reported as a revealing symptom of TC hamartomas. Here we describe an atyp...

Introduction: Pituitary adenomas stand as the most prevalent form of tumorous pathology impacting the pituitary gland in adults. Their discovery might arise from either hypersecretion in functional adenomas or the manifestation of compression symptoms on neighboring structures. Detection of a pituitary adenoma can occur incidentally during various imaging modalities, encompassing both structural and functional assessments. This study documents a case involving the incidental d...

Introduction: Primary hypothyroidism is a common cause of hyperprolactinemia. TSH measurement is part of the first-line investigation of hyperprolactinemia wich usually disappear after L-thyroxine therapy. the presence of pituitary hyperplasia mimicking a pituitary macroadenoma has been reported by several authors, but coexistence oh primary hypothyroidism and prolactinoma is rarely reported.Case: We report a rare case of hyperprolactinemia revealing the...

Introduction: Pregnancy induces significant hormonal alterations, potentially affecting thyroid hormones. Our study aimed to assess the prevalence of thyroid dysfunction in pregnant women diagnosed with gestational diabetes Mellitus (GDM).Methods: A descriptive study was conducted, including 197 pregnant women diagnosed with GDM, under the care and monitoring at the Diabetology, Endocrinology department in Farhat Hached university Hospital, Sousse Tunisi...

Introduction: During pregnancy, women experience various physiological changes that can impact them psychologically. Lifestyle modifications such as eating behaviors and physical activity during this period are major determinants of pregnancy outcomes, child development, and maternal health. Also, body transformations during this period could reactivate concerns regarding body image and introduce anxiety, body dissatisfaction, and eating behavior issues. The aim of our study w...